Efficacy of FOLFIRI as a second-line in extrapulmonary poorly-differentiated neuroendocrine carcinoma
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چکیده
منابع مشابه
Efficacy of topotecan in pretreated metastatic poorly differentiated extrapulmonary neuroendocrine carcinoma
Therapeutic options for metastatic poorly differentiated neuroendocrine carcinoma (NEC) after prior platinum-based chemotherapy are limited. Topotecan is an approved second-line chemotherapy for small cell lung cancer (SCLC). NEC is often considered to show a biological behavior similar to SCLC. The aim of this study was to analyze the efficacy of topotecan in pretreated metastatic NEC patients...
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Poorly differentiated neuroendocrine carcinoma is a rare malignancy that remains a challenge to treat. Poorly differentiated neuroendocrine carcinoma occurs at an incidence of 2% annually in United States. The current standard of care is based largely upon retrospective data. There remains a need for large prospective cooperative group trials in the management of poorly differentiated neuroendo...
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Pancreatic poorly differentiated neuroendocrine tumors (PDNETs) are a subtype of neuroendocrine tumors (NETs) that are clinically distinguished by their very rapid growth. They are immunohistochemically diagnosed by having a higher Ki-67 cancer cell staining percentage when compared with well or intermediately differentiated NETs. These tumors are typically treated in the same manner as small c...
متن کاملCisplatin and etoposide as first-line chemotherapy for poorly differentiated neuroendocrine carcinoma of the hepatobiliary tract and pancreas.
OBJECTIVE The combination chemotherapy consisting of cisplatin and etoposide, one of the standard regimens for small cell lung cancer, has been widely used to treat extrapulmonary poorly differentiated neuroendocrine carcinomas. However, there were no prior reports limited to the hepatobiliary tract and pancreas as the primary sites. METHODS We reviewed the cases in our database from October ...
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The production of serotonin (5-hydroxtryptamine) and certain related metabolites by tumours associated with the clinical carcinoid syndrome has now been well established. Many of the reported cases have concerned carcinoid tumours of the intestinal tract (Thorson, 1958 ; Macfarlane, Dalgliesh, Dutton, Lennox, Nyhus, and Smith, 1956) but tumours histologically resembling carcinoids, and also app...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 2019
ISSN: 0923-7534
DOI: 10.1093/annonc/mdz155.309